Laboratory Automation Equipment Operation Guide
Laboratory automation equipment increases throughput, improves reproducibility, and reduces human error in repetitive laboratory tasks. Proper operation and maintenance ensure reliable automated workflows.
I. Types of Automation
- Liquid Handlers: Automated pipetting systems for precise liquid transfer in microplate formats. Used in high-throughput screening, assay preparation, and sample dilution.
- Robotic Arms: Move plates, tubes, and labware between instruments. Enable integrated, walkaway automation.
- Automated Storage: Temperature-controlled storage and retrieval systems for compound libraries and biological samples.
- Integrated Systems: Combine multiple instruments into a complete automated workflow with scheduling software.
II. Operation
- Perform daily system checks including instrument self-diagnostics, tip inventory, and waste container levels
- Load labware and reagents as defined in the automated protocol
- Verify the run parameters before starting the automated workflow
- Monitor the initial cycles to confirm proper operation
- Review run logs for errors or warnings after completion
III. Maintenance
- Daily: Clean liquid handler tips and wash stations. Empty waste containers. Check system fluids.
- Weekly: Verify liquid handler accuracy and precision using gravimetric testing. Clean robotic grippers.
- Monthly: Lubricate robot joints and rails. Calibrate robot positions. Verify sensor functionality.
- Quarterly: Professional preventive maintenance including belt tension checks, system calibration, and software updates.
