MC is the least toxic of the simple chlorohydrocarbons, but it is not without health risks, as its high volatility makes it an acute inhalation hazard.[16][17] It can also be absorbed through the skin.[1][13]

Symptoms of acute overexposure to dichloromethane via inhalation include difficulty concentrating, dizziness, fatigue, nausea, headaches, numbness, weakness, and irritation of the upper respiratory tract and eyes. More severe consequences can include suffocation, loss of consciousness, coma, and death.